Endocrine Abstracts

BackgroundDiabetes Insipidus is a complex and heterogeneous clinical syndrome affecting water balance, resulting in large volumes of dilute urine. Determining the mechanism and etiology of diabetes insipidus, as well as differentiating it from other pathologies that cause polyuria and polydipsia has always been a challenge since water deprivation test is not always conclusive and antidiuretic hormone can not be reliably measured in the circulation.<p...

IntroductionHypopituitarism is the partial or complete loss of anterior pituitary function that can result from acquired or congenital causes. Understanding its clinical aspects in children could lead to early diagnosis and therefore better outcome.ObjectiveThe aim of this study is to evaluate the characteristics of presentation, and etiology of Hypopituitarism in children.Methods<p...

IntroductionGynecomastia is the most common breast condition in men. The aim of our study is to describe clinical and therapeutic characteristics of patients with gynecomastia.MethodsA descriptive retrospective study was conducted in the department of endocrinology at the Hedi Chaker hospital, Sfax, Tunisia.ResultsWe collected the data of 28 patients with an avera...

IntroductionThe synthetic anti-oestrogen tamoxifen is the endocrine treatment modality most commonly used for therapy of hormone sensitive breastcancer. The influence of tamoxifen on thyroid function has not been fully elucidated.ObservationA 46-year-old female patient who presented a Graves’ disease diagnosed 10 years ago. She had a moderate vascular goiter and no ocular signs. She presented firstly a s...

IntoductionThe link between hyperthyroidism and breast cancer has been the subject of much controversy and literature in the past. It poses a daily clinical problem of information and senological follow-up of thyroid patients. We report our patient’s case.ObservationA 46-year-old female patient who presented a Graves’ disease diagnosed 10 years ago. She had a moderate vascular goiter and no ocular s...

Introduction: Primary hyperaldosteronism (PA) is the autonomous production of aldosterone by a disease primarily affecting the glomerular zone of the adrenal gland. It is one of the most frequent causes of secondary hypertension. The diagnosis should be suspected in the presence of the classic clinico-biological triad in patients presenting with hypertension, low plasma renin activity (PRA), with or without hypokalemia.Patients and Methods: Retrospective...

Introduction: Primary aldosteronism (PA) is commonly identified as the main cause of secondary hypertension. It is becoming increasingly wide-spread, affecting between 1 and 30% of people suffering from hypertension. We aim to describe the epidemiological, clinical and paraclinical characteristics of PA and to analyse its therapeutic and evolutionary aspects.Patients and methods: Retrospective and descriptive study concerning 40 patients with PA, collect...

Introduction: Primary aldosteronism (PA) is commonly identified as the main cause of secondary hypertension. It is becoming increasingly wide-spread, affecting between 1 and 30% of people suffering from hypertension. We aim to determine the different characteristics between aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH).Patients and methods: Retrospective descriptive and analytical study concerning 40 patients with PA, collec...

Introduction: Advances in diagnosis and treatment over the years have improved the life expectancy and quality of life for individuals with congenital adrenal hyperplasia (CAH). The inevitable alteration of the hypercortisolism-hyperandrogenism balance with current CAH therapy could be responsible for several anomalies in the gonadotropic axis and compromise fertility. This study aims to investigate this aspect in an aging Tunisian population of patients with CAH.<p class=...

Introduction: Primary aldosteronism (PA) is commonly identified as the main cause of secondary hypertension. It is becoming increasingly wide-spread, affecting between 1 and 30% of people suffering from hypertension. A prolonged exposure to high aldosterone concentrations has a deleterious effect on cardiovascular tissues and is associated with target organ damage, independently of blood pressure, so a higher risk of cardiovascular events has been reported in patients with pri...